Verapamil Hydrochloride Injection

Name: Verapamil Hydrochloride Injection

Side effects

The following reactions were reported with verapamil hydrochloride injection used in controlled U.S. clinical trials involving 324 patients:

Cardiovascular: Symptomatic hypotension (1.5%); bradycardia (1.2%); severe tachycardia (1.0%). The worldwide experience in open clinical trials in more than 7,900 patients was similar.

Central Nervous System Effects : Dizziness (1.2%); headache (1.2%). Occasional cases of seizures during verapamil injection have been reported.

Gastrointestinal: Nausea (0.9%); abdominal discomfort (0.6%).

In rare cases of hypersensitive patients, broncho/laryngeal spasm accompanied by itch and urticaria has been reported.

The following reactions have been reported at low frequency: emotional depression, rotary nystagmus, sleepiness, vertigo, muscle fatigue, diaphoresis, and respiratory failure.

Suggested Treatment of Acute Cardiovascular Adverse Reactions *

The frequency of these adverse reactions was quite low, and experience with their treatment has been limited.
Adverse Reaction Proven Effective Treatment Supportive Treatment
1. Symptomatic hypotension requiring treatment Dopamine I.V.
Calcium chloride I.V.
Norepinephrine bitartrate I.V.
Metaraminol bitartrate I.V.
Isoproterenol HCl I.V.
Intravenous fluids Trendelenburg position
2. Bradycardia, AV block, Asystole Isoproterenol HCl I.V.
Calcium chloride I.V.
Norepinephrine bitartrate I.V.
Atropine I.V.
Cardiac pacing
Intravenous fluids (slow drip)
3. Rapid ventricular rate (due to antegrade conduction in flutter/fibrillation with W-P-W or L-G-L syndromes) DC-cardioversion (high energy may be required)
Procainamide I.V.
Lidocaine I.V.
Intravenous fluids (slow drip)
*Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician.

Read the entire FDA prescribing information for Verapamil Hydrochloride (Verapamil Hydrochloride Injection)

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© Verapamil Hydrochloride Patient Information is supplied by Cerner Multum, Inc. and Verapamil Hydrochloride Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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