Timentin

Name: Timentin

Uses for Timentin

Bone and Joint Infections

Treatment of bone and joint infections caused by β-lactamase-producing Staphylococcus aureus.1 78

Gynecologic Infections

Treatment of gynecologic infections (e.g., endometritis) caused by β-lactamase-producing S. aureus, S. epidermidis, Enterobacter (including E. cloacae), Escherichia coli, Klebsiella pneumoniae, or Prevotella melaninogenicus.1 98 99 100 101 102 103 104 66

Intra-abdominal Infections

Treatment of intra-abdominal infections (e.g., peritonitis) caused by β-lactamase-producing E. coli, K. pneumoniae, or Bacteroides fragilis group.1 103 104 105 106 113 114 115 116 117 127 128

Respiratory Tract Infections

Treatment of lower respiratory tract infections caused by β-lactamase-producing S. aureus, Haemophilus influenzae, or Klebsiella.1 76 77 79 106

Septicemia

Treatment of septicemia caused by β-lactamase-producing S. aureus, E. coli, Klebsiella, or Pseudomonas (including Ps. aeruginosa).1 76 77 79 106

Skin and Skin Structure Infections

Treatment of skin and skin structure infections caused by β-lactamase-producing S. aureus, E. coli, or Klebsiella.1 76 77 79

Urinary Tract Infections (UTIs)

Treatment of uncomplicated or complicated UTIs caused by β-lactamase-producing S. aureus, Citrobacter, E. cloacae, E. coli, Klebsiella, Pseudomonas (including Ps. aeruginosa), or Serratia marcescens.1 76 77 79 106

Interactions for Timentin

Specific Drugs

Drug

Interaction

Aminoglycosides

In vitro evidence of additive or synergistic antibacterial effects against Enterobacteriaceae and Ps. aeruginosa1 8 11 15 16 17 18 46

Probenecid

Increased ticarcillin serum concentrations and prolonged half-life;1 pharmacokinetics of clavulanate not affected1

Actions and Spectrum

  • Fixed combination of ticarcillin disodium (an extended-spectrum penicillin) and clavulanate potassium (a β-lactamase inhibitor).1 3 4 7 9 10 21 55 77 97

  • Clavulanate potassium synergistically expands ticarcillin’s spectrum of activity against β-lactamase-producing bacteria by irreversibly and completely inhibiting β-lactamase.1 9 19 20 21 55 69 70 73 74 75 77

  • Usually bactericidal.1

  • Like other β-lactam antibiotics, antibacterial activity results from inhibition of bacterial cell wall synthesis.1

  • Spectrum of activity includes many gram-positive and -negative aerobes and some anaerobes.1 Inactive against mycobacteria, Mycoplasma, Rickettsia, fungi, and viruses.a

  • Gram-positive aerobes: active in vitro and in clinical infections against S. aureus and S. epidermidis.1 Also active in vitro against Streptococcus pneumoniae (penicillin-susceptible strains only), S. agalactiae (group B streptococci), S. pyogenes (group A β-hemolytic streptococci), S. bovis, and viridans streptococci.1 Oxacillin-resistant (methicillin-resistant) staphylococci are resistant.1

  • Gram-negative aerobes: active in vitro and in clinical infections against Citrobacter, Enterobacter (including E. cloacae), Escherichia coli, Haemophilus influenzae (except β-lactamase-negative, ampicillin-resistant strains; BLNAR), Klebsiella (including K. pneumoniae), Pseudomonas (including Ps. aeruginosa), and Serratia marcescens.1 Also active in vitro against Acinetobacter, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Pasteurella multocida, Proteus mirabilis, P. penneri, P. vulgaris, Providencia, and Stenotrophomonas maltophilia.1 Pseudomonas resistant to ticarcillin generally also are resistant to ticarcillin and clavulanate.69 70

  • Anaerobes: active in vitro and in clinical infections against Bacteroides fragilis group and Prevotella melaninogenicus.1 Also active in vitro against Clostridium, Eubacterium, Fusobacterium, Peptostreptococcus, and Veillonella.1

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Ticarcillin Disodium and Clavulanate Potassium

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

For injection

3 g (of ticarcillin) and 100 mg (of clavulanic acid) (labeled as a combined total potency of 3.1 g)

Timentin

GlaxoSmithKline

30 g (of ticarcillin) and 1 g (of clavulanic acid) (labeled as a combined total potency of 31 g) pharmacy bulk package

Timentin

GlaxoSmithKline

For injection, for IV infusion

3 g (of ticarcillin) and 100 mg (of clavulanic acid) (labeled as a combined total potency of 3.1 g)

Timentin ADD-Vantage

GlaxoSmithKline

Ticarcillin Disodium and Clavulanate Potassium in Water

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

Injection (frozen) for IV infusion

30 mg (of ticarcillin) per mL (3 g) and 1 mg (of clavulanic acid) per mL (100 mg) (labeled as a combined total potency of 3.1 g)

Timentin Iso-osmotic in Sterile Water Injection (Galaxy [Baxter])

GlaxoSmithKline

Before Using Timentin

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of ticarcillin and clavulanate combination in children. However, safety and efficacy have not been established in infants younger than 3 months of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of ticarcillin and clavulanate combination in the elderly. However, elderly patients are more likely to have age-related kidney or heart problems, which may require an adjustment in the dose for patients receiving ticarcillin and clavulanate combination.

Pregnancy

Pregnancy Category Explanation
All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Bupropion
  • Donepezil
  • Methotrexate
  • Warfarin

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Allergy to cephalosporin or penicillin antibiotics, history of— Should not be used in patients with this condition.
  • Bleeding problems or
  • Congestive heart failure or
  • Diarrhea or
  • Hypokalemia (low potassium in the blood)—Use with caution. May make these conditions worse.
  • Kidney disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

How do I store and/or throw out Timentin?

  • If you need to store Timentin at home, talk with your doctor, nurse, or pharmacist about how to store it.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
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