Siltuximab Injection

Name: Siltuximab Injection

How should this medicine be used?

Siltuximab injection comes as a liquid to be injected intravenously (into a vein) over 1 hour by a healthcare provider in a hospital or medical office. It is usually given once every 3 weeks.

You may experience a reaction when you receive siltuximab injection. If you experience a reaction, your healthcare provider will stop your infusion and will give you medication to treat your reaction. If your reaction is severe, your healthcare provider may not give you any more infusions of siltuximab. Tell your healthcare provider if you experience any of the following symptoms during or after your infusion: trouble breathing; chest tightness; wheezing; dizziness or light-headedness; swelling of the face, lips, tongue or throat; rash; back pain; chest pain; nausea; vomiting; flushing; reddening of the skin; or pounding heartbeat.

Siltuximab injection may help to control MCD but does not cure it. Continue to keep appointments to receive siltuximab injection even if you feel well.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

What special precautions should I follow?

Before receiving siltuximab injection,

  • tell your doctor and pharmacist if you are allergic to siltuximab injection, any other medications, or any of the ingredients in siltuximab injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven), atorvastatin (Lipitor), cyclosporine (Gengraf, Neoral, Sandimmune), lovastatin (in Advicor, in Altoprev), oral contraceptives (birth control pills), and theophylline (Theolair, Theo-24, Uniphyl). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • tell your doctor if you have any type of infection before you begin your treatment with siltuximab injection, or if you notice any signs of infection during your treatment. Also tell your doctor if you have or have ever had any condition that affects your stomach or intestines such as ulcers (sores in the lining of the stomach or intestines) or diverticulitis (small pouches in the lining of the intestine that may become inflamed).
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should use birth control to prevent pregnancy during your treatment with siltuximab injection and for three months after your treatment. Talk to your doctor about methods of birth control that will work for you. If you become pregnant while receiving siltuximab injection, call your doctor immediately. Siltuximab may harm the fetus.
  • do not have any vaccinations without talking to your doctor. Also tell your doctor if you have recently received any vaccinations. Talk to your doctor about whether you should receive any vaccinations before you begin your treatment.

What side effects can this medication cause?

Siltuximab injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • darkening of the skin
  • dry skin
  • constipation
  • stomach pain or swelling
  • loss of appetite
  • mouth or throat pain
  • headache

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • fever
  • chills
  • nausea
  • vomiting
  • unusual bruising or bleeding
  • swelling of the hands, arms, feet, ankles, or lower legs

Siltuximab injection may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Brand names

  • Sylvant┬«