Pentamidine (Inhalation Route)

Name: Pentamidine (Inhalation Route)

US Brand Name

  1. Nebupent

Descriptions

Pentamidine is used to try to prevent Pneumocystis carinii pneumonia (PCP), a very serious type of pneumonia. This type of pneumonia occurs commonly in patients whose immune systems are not working normally, such as patients with acquired immune deficiency syndrome (AIDS). Inhaled pentamidine does not prevent illness in parts of the body outside the lungs. This medicine may also be used for other conditions as determined by your doctor.

Pentamidine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of pentamidine inhalation in children with use in other age groups. However, pentamidine inhalation is recommended in children 5 years of age and older who cannot tolerate other medicines.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Amifampridine
  • Amisulpride
  • Bepridil
  • Cisapride
  • Dronedarone
  • Grepafloxacin
  • Levomethadyl
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Acetophenazine
  • Ajmaline
  • Amiodarone
  • Amitriptyline
  • Amoxapine
  • Anagrelide
  • Aprindine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether
  • Astemizole
  • Azimilide
  • Azithromycin
  • Bretylium
  • Buserelin
  • Chloral Hydrate
  • Chloroquine
  • Chlorpromazine
  • Cidofovir
  • Citalopram
  • Clarithromycin
  • Clozapine
  • Crizotinib
  • Dabrafenib
  • Degarelix
  • Delamanid
  • Desipramine
  • Deslorelin
  • Dibenzepin
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Droperidol
  • Efavirenz
  • Encainide
  • Enflurane
  • Erythromycin
  • Escitalopram
  • Ethopropazine
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluphenazine
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Imipramine
  • Isoflurane
  • Isradipine
  • Ivabradine
  • Ketoconazole
  • Leuprolide
  • Levofloxacin
  • Lidoflazine
  • Lorcainide
  • Lumefantrine
  • Mefloquine
  • Methadone
  • Methotrimeprazine
  • Metronidazole
  • Moxifloxacin
  • Nafarelin
  • Nilotinib
  • Nortriptyline
  • Octreotide
  • Ondansetron
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Perphenazine
  • Pimavanserin
  • Pipotiazine
  • Pirmenol
  • Pitolisant
  • Prajmaline
  • Probucol
  • Procainamide
  • Prochlorperazine
  • Promazine
  • Promethazine
  • Propafenone
  • Propiomazine
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Risperidone
  • Sematilide
  • Sertindole
  • Sevoflurane
  • Sotalol
  • Spiramycin
  • Sulfamethoxazole
  • Sulpiride
  • Sultopride
  • Tacrolimus
  • Tedisamil
  • Telithromycin
  • Thiethylperazine
  • Tizanidine
  • Trifluoperazine
  • Triflupromazine
  • Trimeprazine
  • Trimethoprim
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vasopressin
  • Vemurafenib
  • Vinflunine
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For the inhalation dosage form:
    • For the prevention of Pneumocystis carinii pneumonia (PCP):
      • Adults and children 5 years of age and older—300 milligrams (mg) by oral inhalation once every four weeks.
      • Children younger than 5 years of age—Use and dose must be determined by your doctor.
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