Norphyl

Name: Norphyl

Commonly used brand name(s)

In the U.S.

  • Elixophyllin
  • Norphyl
  • Phyllocontin
  • Quibron-T
  • Quibron-T/SR
  • Theo-24
  • TheoCap
  • Theochron
  • Theo-Dur
  • Theo-Time
  • Truxophyllin
  • Uniphyl

Available Dosage Forms:

  • Elixir
  • Solution
  • Tablet, Extended Release, 12 HR
  • Tablet
  • Capsule, Extended Release, 24 HR
  • Capsule, Extended Release
  • Tablet, Extended Release
  • Capsule, Extended Release, 12 HR
  • Syrup
  • Capsule
  • Tablet, Extended Release, 24 HR
  • Tablet, Enteric Coated

Therapeutic Class: Bronchodilator

Chemical Class: Methylxanthine

Usual Geriatric Dose for Asthma - Acute

Loading dose: 5 mg/kg loading dose (patient not receiving theophylline or aminophylline).

Otherwise healthy, nonsmokers: 10 mg/kg/day. Do not exceed 900 mg/day

Patient with congestive heart failure, cor pulmonale, and/or liver dysfunction: 5 mg/kg/day. Do not exceed 400 mg/day

Usual Geriatric Dose for Asthma - Maintenance

Loading dose: 5 mg/kg loading dose (patient not receiving theophylline or aminophylline).

Otherwise healthy, nonsmokers: 10 mg/kg/day. Do not exceed 900 mg/day

Patient with congestive heart failure, cor pulmonale, and/or liver dysfunction: 5 mg/kg/day. Do not exceed 400 mg/day

Usual Pediatric Dose for Asthma - Acute

Loading dose:
If no theophylline has been administered in the previous 24 hours: 5 mg/kg loading dose to achieve a serum concentration of about 10 mcg/mL; loading doses should be given using a rapidly absorbed oral product not a sustained release product).

If theophylline has been administered in the previous 24 hours: 2.5 mg/kg theophylline may be given in emergencies when serum concentrations are not available. A modified loading dose (mg/kg) may be calculated (when the serum level is known) by: [Blood concentration desired - blood concentration measured] divided by 2 (for every 1 mg/kg theophylline given, the blood level will rise by approximately 2 mcg/mL).

Maintenance dose:

less than 42 days: 4 mg/kg/day orally.

42 days to 181 days: 10 mg/kg/day orally. Alternate dosing: [(0.2 x age in weeks) + 5] x kg = 24 hour oral dose in milligrams.

6 months less than 12 months: 12 to 18 mg/kg/day. Alternate dosing: [(0.2 x age in weeks) + 5] x kg = 24 hour oral dose in milligrams.

1 year to 8 years: 20 to 24 mg/kg/day.

9 years to 11 years: 16 mg/kg/day.

12 years to 15 years: 13 mg/kg/day.

16 years or older: 10 mg/kg/day. Do not exceed 900 mg/day.

Dialysis

Theophylline is somewhat removed with hemodialysis. A 50% supplemental dose or administering the dose post dialysis is recommended. A supplemental dose is not needed with peritoneal dialysis.

(web3)