Norepinephrine Injection Concentrate
Name: Norepinephrine Injection Concentrate
- Norepinephrine Injection Concentrate injection
- Norepinephrine Injection Concentrate 1 mg
- Norepinephrine Injection Concentrate action
- Norepinephrine Injection Concentrate 4 mg
- Norepinephrine Injection Concentrate brand name
- Norepinephrine Injection Concentrate names
- Norepinephrine Injection Concentrate drug
Norepinephrine Injection Concentrate Description
Norepinephrine (sometimes referred to as l-arterenol/Levarterenol or l-norepinephrine) is a sympathomimetic amine which differs from epinephrine by the absence of a methyl group on the nitrogen atom.
Norepinephrine bitartrate, USP is (-)-α-(aminomethyI)-3,4-dihydroxybenzyl alcohol tartrate (1:1) (salt) monohydrate and has the following structural formula:
C8H11NO3·C4H6O6·H2O M.W. 337.28
Norepinephrine Bitartrate Injection USP is supplied in sterile aqueous solution in the form of the bitartrate salt to be administered by intravenous infusion following dilution. Norepinephrine is sparingly soluble in water, very slightly soluble in alcohol and ether, and readily soluble in acids. Each mL contains the equivalent of 1 mg base of norepinephrine, sodium chloride for isotonicity, and not more than 2 mg of sodium metabisulfite as an antioxidant. It has a pH of 3.0 to 4.5. The air in the vials has been displaced by nitrogen gas.
Norepinephrine bitartrate injection should not be given to patients who are hypotensive from blood volume deficits except as an emergency measure to maintain coronary and cerebral artery perfusion until blood volume replacement therapy can be completed. If norepinephrine bitartrate injection is continuously administered to maintain blood pressure in the absence of blood volume replacement, the following may occur: severe peripheral and visceral vasoconstriction, decreased renal perfusion and urine output, poor systemic blood flow despite "normal" blood pressure, tissue hypoxia, and lactate acidosis.
Norepinephrine bitartrate injection should also not be given to patients with mesenteric or peripheral vascular thrombosis (because of the risk of increasing ischemia and extending the area of infarction) unless, in the opinion of the attending physician, the administration of norepinephrine bitartrate injection is necessary as a life-saving procedure.
Cyclopropane and halothane anesthetics increase cardiac autonomic irritability and therefore seem to sensitize the myocardium to the action of intravenously administered epinephrine or norepinephrine. Hence, the use of norepinephrine bitartrate injection during cyclopropane and halothane anesthesia is generally considered contraindicated because of the risk of producing ventricular tachycardia or fibrillation.
The same type of cardiac arrhythmias may result from the use of norepinephrine bitartrate injection in patients with profound hypoxia or hypercarbia.
Overdosage with norepinephrine bitartrate injection may result in headache, severe hypertension, reflex bradycardia, marked increase in peripheral resistance, and decreased cardiac output. In case of accidental overdosage, as evidenced by excessive blood pressure elevation, discontinue norepinephrine bitartrate injection until the condition of the patient stabilizes.
How is Norepinephrine Injection Concentrate Supplied
Norepinephrine Bitartrate Injection USP contains the equivalent of 4 mg base of norepinephrine bitartrate, USP per each 4 mL vial (1 mg/mL), and is available as follows:
|NDC Number||Size||Package Size|
4 mL amber
Store at 20º to 25ºC (68º to 77ºF) [See USP Controlled Room Temperature]. Protect from light.
All brand names listed are the registered trademarks of their respective owners and are not trademarks of Teva Pharmaceuticals USA.
Rev. A 3/2015
TEVA PHARMACEUTICALS USA, INC.
North Wales, PA 19454
Package/Label Display Panel
Norepinephrine Bitartrate Injection USP 1 mg/mL, 4 mL x 10 Vials, Carton TextNDC 0703-1153-03 Rx only
Bitartrate Injection USP
FOR IV INFUSION ONLYProtect from Light. 10 Vials
|NOREPINEPHRINE BITARTRATE |
norepinephrine bitartrate injection, solution, concentrate
|Labeler - Teva Parenteral Medicines, Inc. (794362533)|