Neo-Fradin

Name: Neo-Fradin

What happens if i miss a dose (neo-fradin, neo-tab)?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Proper Use of Neo-Fradin

This medicine may be taken on a full or empty stomach.

For patients taking the oral liquid form of neomycin:

  • Use a specially marked measuring spoon or other device to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.

Keep taking this medicine for the full time of treatment. Do not miss any doses.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (solution, tablets):
    • For patients in a coma from liver disease:
      • Adults and teenagers—1 to 3 grams every six hours for five or six days.
      • Children—Dose is based on body size (not weight) and must be determined by your doctor. That dose is given every six hours for five or six days.
    • For cleaning the bowel before surgery:
      • Adults and teenagers—1 gram every hour for four hours, then 1 gram every four hours for the rest of a twenty-four hour period; or 1 gram nineteen hours before surgery, 1 gram eighteen hours before surgery, and 1 gram nine hours before surgery.
      • Children—Dose is based on body weight. The usual dose is 14.7 milligrams (mg) per kilogram (kg) (6.7 mg per pound) of body weight every four hours for three days.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

What do I need to tell my doctor BEFORE I take Neo-Fradin?

  • If you have an allergy to neomycin or any other part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have any of these health problems: Bowel block or ulcers in your stomach or bowels.
  • If you are breast-feeding or plan to breast-feed.

This is not a list of all drugs or health problems that interact with Neo-Fradin.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Neo-Fradin?

  • Tell all of your health care providers that you take Neo-Fradin. This includes your doctors, nurses, pharmacists, and dentists.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • Do not use longer than you have been told. A second infection may happen.
  • Use with care in children. Talk with the doctor.
  • If you are 65 or older, use this medicine with care. You could have more side effects.
  • This medicine may cause harm to the unborn baby if you take it while you are pregnant.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Neo-Fradin while you are pregnant.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Neomycin Pregnancy Warnings

Neomycin has been assigned to pregnancy category D by the FDA. Animal studies have not been reported. There are no controlled data in human pregnancy; however, other aminoglycoside antibiotics cross the placenta. Streptomycin use in pregnancy has been associated with irreversible bilateral deafness in children. Serious fetal side effects have not been reported with other aminoglycosides. Patients should be warned of potential hazards to the fetus if they if take neomycin during pregnancy or become pregnant while taking this drug.

Neomycin Levels and Effects while Breastfeeding

Summary of Use during Lactation

Although no information exists on the excretion of neomycin into milk, other aminoglycoside antibiotics are poorly excreted into breastmilk. Newborn infants apparently absorb small amounts of aminoglycosides, but serum levels are far below those attained when treating newborn infections and systemic effects of neomycin are unlikely. Older infants would be expected to absorb even less neomycin. Monitor the infant for possible effects on the gastrointestinal flora, such as diarrhea, candidiasis (e.g., thrush, diaper rash) or rarely, blood in the stool indicating possible antibiotic-associated colitis.

Oral, topical, ophthalmic or otic neomycin should result in very low levels in breastmilk and present negligible risk to the infant,[1][2] although topical application to the nipple may increase the risk of diarrhea in the infant. Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[3]

Drug Levels

Maternal Levels. Relevant published information was not found as of the revision date.

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Effects on Lactation and Breastmilk

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

(Injection) Gentamicin, Kanamycin, Tobramycin, (Topical) Bacitracin, Clindamycin, Mupirocin, Polymyxin B

References

1. Niebyl JR. Use of antibiotics for ear, nose, and throat disorders in pregnancy and lactation. Am J Otolaryngol. 1992;13:187-92. PMID: 1503194

2. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24:167-97. PMID: 16677965

3. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38:317-25. PMID: 14623482

Administrative Information

LactMed Record Number

197

Last Revision Date

20150310

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

(web3)