Metronidazole Topical Gel

Name: Metronidazole Topical Gel

Clinical pharmacology

Bioavailability studies on the topical administration of 1 gram of METROGEL® Topical Gel (7.5 mg of metronidazole) to the face of 10 rosacea patients showed a maximum serum concentration of 66 nanograms per milliliter in one patient. This concentration is approximately 100 times less than concentrations afforded by a single 250 mg oral tablet. The serum metronidazole concentrations were below the detectable limits of the assay at the majority of time points in all patients. Three of the patients had no detectable serum concentrations of metronidazole at any time point. The mean dose of gel applied during clinical studies was 600 mg which represents 4.5 mg of metronidazole per application. Therefore, under normal usage levels, the formulation affords minimal serum concentrations of metronidazole. The mechanisms by which METROGEL® (metron-idazole topical gel) Topical Gel acts in the treatment of rosacea are unknown, but appear to include an anti-inflammatory effect.

Patient information

This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.

What is the most important information i should know about metronidazole topical (metrocream, metrogel, metrolotion, noritate)?

Do not use metronidazole topical if you have ever had an allergic reaction to it.

Before using metronidazole topical, tell your doctor if you are allergic to any drugs, or if you have a blood cell disorder such as anemia or decreased white blood cells.

Tell your doctor about all other medications you use, especially a blood thinner such as warfarin (Coumadin).

Metronidazole topical is for use only on the skin. Avoid getting this medication in your eyes. If this does happen, rinse thoroughly with cool water. Do not use topical metronidazole in the vagina.

Call your doctor if you have severe stinging or burning when you apply metronidazole topical.

Use this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before any infection is completely treated. Do not use metronidazole topical to treat any other skin infection your doctor has not prescribed it for.

What should i avoid while using metronidazole topical (metrocream, metrogel, metrolotion, noritate)?

Metronidazole topical is for use only on the skin. Avoid getting this medication in your eyes. If this does happen, rinse thoroughly with cool water. Do not use topical metronidazole in the vagina.

Where can i get more information?

Your pharmacist can provide more information about metronidazole topical.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Side effects

The following adverse experiences have been reported with the topical use of metronidazole: burning, skin irritation, dryness, transient redness, metallic taste, tingling or numbness of extremities and nausea.

Read the entire FDA prescribing information for MetroGel 75 (Metronidazole Topical Gel)

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