Methylfolate

Name: Methylfolate

What are some things I need to know or do while I take Methylfolate?

  • Tell all of your health care providers that you take methylfolate. This includes your doctors, nurses, pharmacists, and dentists.
  • Talk with your doctor before you drink alcohol.
  • If you smoke, talk with your doctor.
  • Have blood work checked as you have been told by the doctor. Talk with the doctor.
  • If you are allergic to tartrazine, talk with your doctor. Some products have tartrazine.
  • If you take cholestyramine or colestipol, talk with your pharmacist about how to take them with this medicine.
  • This medicine may affect how much of some other drugs are in your body. If you are taking other drugs, talk with your doctor. You may need to have your blood work checked more closely while taking methylfolate with your other drugs.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

Deplin 7.5: L-methylfolate 7.5 mg and Schizochytrium algae [contains fd&c red #40, fd&c yellow #6 (sunset yellow), fd&c yellow #6 aluminum lake, sodium caseinate, soy protein, soybean lecithin]

Deplin 15: L-methylfolate 15 mg and Schizochytrium algae [contains fd&c red #40, fd&c yellow #6 (sunset yellow), sodium caseinate, soy protein, soybean lecithin]

L-Methylfolate Formula 15: L-methylfolate 15 mg and Schizochytrium algae [contains sodium caseinate, soy protein, soybean lecithin]

L-Methylfolate Formula 7.5: L-methylfolate 7.5 mg and Schizochytrium algae [contains sodium caseinate, soy protein, soybean lecithin]

L-Methylfolate Forte: L-methylfolate 7.5 mg and Schizochytrium algae [contains fd&c red #40, fd&c yellow #6 (sunset yellow), fd&c yellow #6 aluminum lake, sodium caseinate, soy protein, soybean lecithin]

L-Methylfolate Forte: L-methylfolate 15 mg and Schizochytrium algae [contains sodium caseinate, soy protein, soybean lecithin]

Generic: L-methylfolate 15 mg and Schizochytrium algae [DSC], L-methylfolate 7.5 mg and Schizochytrium algae [DSC]

Tablet, Oral:

Deplin: 7.5 mg [DSC] [gluten free, lactose free, sugar free, yeast free; contains fd&c blue #2 (indigotine)]

Elfolate: 7.5 mg, 15 mg

Generic: 7.5 mg, 15 mg

Brand Names U.S.

  • Deplin 15
  • Deplin 7.5
  • Deplin [DSC]
  • Elfolate
  • L-Methylfolate Formula 15
  • L-Methylfolate Formula 7.5
  • L-Methylfolate Forte

Pharmacologic Category

  • Medical Food

Dosing Geriatric

Refer to adult dosing.

Administration

May be administered with or without food.

Storage

Store at controlled room temperature of 15°C to 30°C (59°F to 86°F). Protect from heat, light, and moisture.

Drug Interactions

CarBAMazepine: Methylfolate may decrease the serum concentration of CarBAMazepine. Monitor therapy

Cholestyramine Resin: May decrease the serum concentration of Methylfolate. Monitor therapy

Colestipol: May decrease the serum concentration of Methylfolate. Monitor therapy

Fosphenytoin: Methylfolate may decrease the serum concentration of Fosphenytoin. Monitor therapy

PHENobarbital: Methylfolate may decrease the serum concentration of PHENobarbital. Monitor therapy

Phenytoin: Methylfolate may decrease the serum concentration of Phenytoin. Monitor therapy

Primidone: Methylfolate may decrease the serum concentration of Primidone. Monitor therapy

Pyrimethamine: Methylfolate may diminish the therapeutic effect of Pyrimethamine. Monitor therapy

Raltitrexed: Methylfolate may diminish the therapeutic effect of Raltitrexed. Avoid combination

SulfaSALAzine: May decrease the serum concentration of Methylfolate. Monitor therapy

Valproate Products: Methylfolate may decrease the serum concentration of Valproate Products. Monitor therapy

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