Magnesium Sulfate, Potassium Sulfate, and Sodium Sulfate

Name: Magnesium Sulfate, Potassium Sulfate, and Sodium Sulfate

How should this medicine be used?

Magnesium sulfate, potassium sulfate, and sodium sulfate comes as a comes as a powder (Colprep®) to mix with water and as a solution (liquid) (Suprep®) to take by mouth. The first dose is usually taken the night before the colonoscopy and the second dose taken the morning of the procedure. Your doctor will tell you exactly when you should take your medication. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take magnesium sulfate, potassium sulfate, and sodium sulfate exactly as directed. Do not take more or less of it than prescribed by your doctor.

To prepare for your colonoscopy, you may not eat any solid food or drink milk beginning the day before the procedure. You should only have clear liquids during this time. Examples of clear liquids are water, light colored fruit juice without pulp, clear broth, coffee or tea without milk, flavored gelatin, popsicles, and soft drinks. Do not drink alcoholic beverages or any liquid that is red or purple. Ask your doctor if you have any questions about which liquids you may drink before your colonoscopy.

If you are taking the solution (Suprep®),you will need to mix the medication solution with water right before you take it. If you swallow the solution without mixing it with water, there is a greater chance that you will experience unpleasant or dangerous side effects. To prepare each dose of your medication, pour the contents of one bottle of magnesium sulfate, potassium sulfate, and sodium sulfate solution into the dosing container that was provided with the medication and fill the container with water up to the line (16 ounces, 480 mL) that is marked on the cup. Drink the entire mixture right away.

If you are taking the powder (Colprep®), you will need to mix the powder with water and then dilute the solution with more water right before you take it. If you swallow the powder without mixing it with water or if you swallow the undiluted solution, there is a greater chance that you will experience unpleasant or dangerous side effects. To prepare each dose of your medication, you must first add water to the bottle that contains the powder. Read the directions that come with your medication to see how much water you should add to the powder. Close the bottle tightly and shake well to dissolve the powder. Pour the contents of the bottle of magnesium sulfate, potassium sulfate, and sodium sulfate solution into the dosing container that was provided with the medication and fill the container with water up to the line (16 ounces, 480 mL) that is marked on the cup. Drink the entire mixture right away.

You will take your first dose on the evening before your colonoscopy. After you take this dose, you will need to drink two 16- ounce (480 mL) containers of water within the next hour before you go to bed. You will take your second dose the next morning before your colonoscopy is scheduled. After you take the second dose, you will need to drink two 16- ounce containers of water within the next hour, but you should finish all the drinks at least 2 hours before your colonoscopy.

You will have many bowel movements during your treatment with magnesium sulfate, potassium sulfate, and sodium sulfate. Be sure to stay close to a toilet from the time you take your first dose of the medication until the time of your colonoscopy appointment. Ask your doctor about other things you can do to stay comfortable during this time.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with this medication. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking magnesium sulfate, potassium sulfate, and sodium sulfate,

  • tell your doctor and pharmacist if you are allergic to magnesium sulfate, potassium sulfate, or sodium sulfate, any other medications, or any of the ingredients in magnesium sulfate, potassium sulfate, and sodium sulfate oral solution. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: alprazolam (Xanax); amiodarone (Cordarone, Pacerone); amitriptyline; angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Epanid, Vasotec, in Vaseretic), fosinopril, lisinopril (Prinivil, Qbrelis, Zestril, in Zestoretic), moexipril, perindopril (Aceon, in Prestalia), quinapril (Accupril, in Accuretic, Quinaretic), ramipril (Altace), or trandolapril (in Tarka); angiotensin II receptor antagonists such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor and Tribenzor), telmisartan (Micardis, in Micardis HCT and Twynsta), and valsartan (Diovan, in Byvalson, Diovan HCT, Entresto, Exforge, and Exforge HCT); aspirin and other nonsteroidal anti-inflammatory medications such as ibuprofen (Motrin) and naproxen (Aleve, Naprosyn); desipramine (Norpramin); diazepam (Diastat, Valium); disopyramide (Norpace); diuretics ('water pills'); dofetilide (Tikosyn); erythromycin (E.E.S., Erythrocin); estazolam; flurazepam; lorazepam (Ativan); medications for seizures; midazolam (Versed); moxifloxacin (Avelox); pimozide (Orap); quinidine (Quinidex, in Nuedexta); sotalol (Betapace, Betapace AF, Sorine); thioridazine; or triazolam (Halcion). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with magnesium sulfate, potassium sulfate, and sodium sulfate, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • do not take any other laxatives during your treatment with magnesium sulfate, potassium sulfate, and sodium sulfate.
  • if you take any medications by mouth, take them at least 1 hour before you start taking magnesium sulfate, potassium sulfate, and sodium sulfate.
  • tell your doctor if you have or have ever had a blockage in your stomach or intestine, an opening in the wall of your stomach or intestine, toxic megacolon (life-threatening widening of the intestine), or any condition that causes problems with the emptying of your stomach or intestine. Your doctor may tell you not to take magnesium sulfate, potassium sulfate, and sodium sulfate.
  • tell your doctor if you have been drinking large amounts of alcohol or taking medications for anxiety or seizures but are now decreasing your use of these substances. Also tell your doctor if you have recently had a heart attack and if you have or have ever had heart failure, an irregular heartbeat, an enlarged heart, a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death), gout, seizures, a low level of sodium, magnesium, potassium, or calcium in your blood, inflammatory bowel disease (conditions such as Crohn's disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) and ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) that cause swelling and irritation in all or part of the intestine), difficulty swallowing, gastric reflux (condition in which backward flow of acid from the stomach causes heartburn and possible injury to the esophagus) or kidney disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding.

What special dietary instructions should I follow?

Your doctor will tell you what you may eat and drink before, during, and after your treatment with magnesium sulfate, potassium sulfate, and sodium sulfate. Follow these directions carefully.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Brand names

  • Colprep®
  • Suprep®
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