Hyaluronidase Injection

Name: Hyaluronidase Injection

Indications

Subcutaneous Fluid Administration

Amphadase® is indicated as an adjuvant in subcutaneous fluid administration for achieving hydration.

Dispersion And Absorption Of Injected Drugs

Amphadase® is indicated as an adjuvant to increase the dispersion and absorption of other injected drugs.

Subcutaneous Urography

Amphadase® is indicated as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.

Patient information

Important Precautions Regarding Hydase™

Instruct patient that Hydase™ is being used to increase the dispersion and absorption of fluids or other injected drugs, as appropriate to the intended use.

What Patients Should Know About Adverse Reactions

The most frequently reported adverse reactions have been mild local injection site reactions such as redness, swelling, itching, or pain.

Anaphylactic-like reactions, and allergic reactions, such as hives, have been reported rarely in patients receiving hyaluronidases.

Patients Should Inform Their Doctors If Taking Other Medications

You may not receive furosemide, the benzodiazepines, phenytoin, dopamine and/or alpha agonists with Hydase™. These medications have been found to be incompatible with hyaluronidase.

If you are taking salicylates (e.g., aspirin), steroids (e.g., cortisone or estrogens) or antihistamines your doctor may need to prescribe larger amounts of hyaluronidase for equivalent dispersing effect.

Overdose

No information provided.

Where can i get more information?

Your pharmacist can provide more information about hyaluronidase injection.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Side effects

The following adverse reactions have been identified during post-approval use of hyaluronidase products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The most frequently reported adverse reactions have been local injection site reactions. Hyaluronidase has been reported to enhance the adverse reactions associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis. Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

Read the entire FDA prescribing information for Amphadase (Hyaluronidase Injection)

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What should i discuss with my health care provider before receiving hyaluronidase (amphadase, hylenex, vitrase)?

You should not receive this medication if you are allergic to it.

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive the medication.

FDA pregnancy category C. It is not known whether hyaluronidase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether hyaluronidase passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

What do I need to tell my doctor BEFORE I take Hyaluronidase Injection?

  • If you have an allergy to hyaluronidase or any other part of hyaluronidase injection.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have an infection or skin problem where the shot will be given.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take hyaluronidase injection with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Hyaluronidase Injection?

  • If you need to store hyaluronidase injection at home, talk with your doctor, nurse, or pharmacist about how to store it.

Uses

Consult your pharmacist.

How to use Hyaluronidase Solution, Reconstituted (Recon Soln)

Consult your pharmacist.

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