- Centany uses
- Centany side effects
- Centany what are the side effects of
- Centany effects of
- Centany used to treat
- Centany is used to treat
- Centany drug
- Centany action
What are the uses for mupirocin?
Mupirocin is used for the treatment of impetigo and infections of the skin caused by Staphylococcus aureus, beta-hemolytic streptococcus or Streptococcus pyogenes. Mupirocin is not recommended for use on the skin in serious burns, because more of the vehicle (the inactive ingredient) used for the ointment, polyethylene glycol (Miralax), may be absorbed and can damage the kidneys. The nasal ointment is used for the elimination of nasal Staphylococcus aureus that have become resistant to other antibiotics. Mupirocin also may be used for other infections as determined by the physician.
What are the side effects of mupirocin?
Side effects are uncommon and mild with mupirocin. The most frequent side effects are:
- pain, and
- itching at the area of application.
Other side effects caused by the intranasal use of mupirocin include:
- runny nose,
- sore throat,
- changes in taste perception,
- nasal irritation,
- and cough.
What is Centany (mupirocin topical)?
Mupirocin is an antibiotic that prevents bacteria from growing on your skin.
Mupirocin topical (for use on the skin) is used to treat skin infections such as impetigo (IM-pe-TYE-go) or a "Staph" infection of the skin.
Mupirocin topical may also be used for purposes not listed in this medication guide.
What should I discuss with my healthcare provider before using Centany (mupirocin topical)?
You should not use this medicine if you are allergic to mupirocin.
To make sure mupirocin topical is safe for you, tell your doctor if you have ever had:
Do not use mupirocin topical on a child without medical advice. The cream should not be used on a child younger than 3 months old. The ointment may be used on a child as young as 2 months old.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
It is not known whether mupirocin topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby. If you apply this medicine to your breast or nipple, wash the areas thoroughly before nursing your baby.
What other drugs will affect Centany (mupirocin topical)?
It is not likely that other drugs you take orally or inject will have an effect on topically applied mupirocin. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.
Centany® (mupirocin ointment, 2%)
For Dermatologic Use Only
Centany - Clinical Pharmacology
Following the application of Centany (mupirocin ointment, 2%) to a 400cm2 area on the back of 23 healthy volunteers once daily for 7 days, the mean (range) cumulative urinary excretion of monic acid over 24 hrs following the last administration was 1.25% (0.2% to 3.0%) of the administered dose of mupirocin. The monic acid concentration in urine collected at specified intervals for 24 hrs on Day 7 ranged from <0.050 to 0.637 µg/mL.
Mupirocin is an antibacterial agent produced by fermentation using the organism Pseudomonas fluorescens. Its spectrum of activity includes gram-positive bacteria. It is also active, in vitro only, against certain gram-negative bacteria. Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. Due to this unique mode of action, mupirocin does not demonstrate cross-resistance with other classes of antimicrobial agents.
When mupirocin resistance occurs, it results from the production of a modified isoleucyl-tRNA synthetase or the acquisition, by genetic transfer, of a plasmid-mediating a new isoleucyl-tRNA synthetase. High-level plasmid-mediated resistance (MIC >500 mcg/mL) has been reported in increasing numbers of isolates of Staphylococcus aureus and with higher frequency in coagulase-negative staphylococci. Methicillin resistance and mupirocin resistance commonly occur together in Staphylococcus aureus and coagulase negative staphylococci.
Mupirocin is bactericidal at concentrations achieved by topical administration. However, the minimum bactericidal concentration (MBC) against relevant pathogens is generally eight-fold to thirty-fold higher than the minimum inhibitory concentration (MIC). In addition, mupirocin is highly protein bound (>97%), and the effect of wound secretions on the MICs of mupirocin has not been determined.
Mupirocin has been shown to be active against susceptible strains of Staphylococcus aureus and Streptococcus pyogenes, both in vitro and in clinical studies (see INDICATIONS AND USAGE).
Indications and Usage for Centany
Centany (mupirocin ointment, 2%) is indicated for the topical treatment of impetigo due to: Staphylococcus aureus and Streptococcus pyogenes.
The efficacy of topical Centany (mupirocin ointment, 2%) in impetigo was tested in one study. Patients with impetigo were randomized to receive either Centany (mupirocin ointment, 2%) or Bactroban® Ointment (mupirocin ointment, 2%) t.i.d. for 7 days. Clinical efficacy rates at the follow-up visit (one week after end of therapy) in the evaluable populations (adults and pediatric patients included) were 94% for Centany (mupirocin ointment, 2%) (n=233) and 95% for Bactroban® Ointment (mupirocin ointment, 2%) (n=242). Pathogen eradication rates at follow-up for both medications were 98%.
There were 413 pediatric patients aged 2 months to 15 years in the clinical study described above. Clinical efficacy rates at follow-up in the evaluable populations were 93% for Centany (mupirocin ointment, 2%) (n=199) and 95% for Bactroban® Ointment (mupirocin ointment, 2%) (n=214).
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(mupirocin ointment, 2%)
For Dermatologic Use Only