Butabarbital

Name: Butabarbital

Adverse Effects

1-10%

Somnolence

<1%

Abnormal thinking

Agitation

Anxiety

Apnea

Ataxia

Bradycardia

CNS depression

Confusion

Constipation

Dizziness

Fever

Hallucination

Headache

Hepatotoxicity

Hypersensitivity rxn

Hypoventilation

Insomnia

Nausea

Nervousness

Nightmares

Psychiatric disturbance

Vomiting

Pharmacology

Mechanism of Action

Interferes with transmission of impulses from the thalamus to the cortex; depresses sensory cortex & decreases motor activity

Pharmacokinetics

Half-Life: ~100 hr

Duration: 6-8 hr

Onset: 45-60 min

Enzymes induced: CYP1A2, CYP2C9/10, CYP3A4

Excretion: Urine

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

When treating insomnia, take butabarbital only when you are getting ready to sleep at least during 7 or 8 hours.

Use Labeled Indications

Sedative/Hypnotic: Use as a sedative or hypnotic.

Contraindications

Hypersensitivity to barbiturates or any component of the formulation; ; history of manifest or latent porphyria

Documentation of allergenic cross-reactivity for barbiturates is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity can not be ruled out with certainty.

Dosing Renal Impairment

There are no dosage adjustments provided in the manufacturer’s labeling; reduced doses are recommended.

Usual Pediatric Dose for Sedation

Preoperative sedation: 2 to 6 mg/kg orally, up to a maximum of 100 mg.

Liver Dose Adjustments

No specific dose adjustment guidelines have been suggested; however, caution and a dose reduction are recommended in patients with liver dysfunction.

Dialysis

Data not available

Butabarbital Identification

Substance Name

Butabarbital

CAS Registry Number

125-40-6

Drug Class

Barbiturates

Hypnotics and Sedatives

GABA Modulators

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