Name: Adrucil injection
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What should I discuss with my healthcare provider before receiving Adrucil (fluorouracil injection)?
You should not receive this medicine if you are allergic to fluorouracil, or if you have:
bone marrow depression;
a serious infection; or
if you are malnourished or are not receiving proper nutrition.
To make sure fluorouracil is safe for you, tell your doctor if you have:
cancer that has spread to your bone marrow;
kidney disease; or
if you have ever had radiation treatment of your pelvic area.
Tell your doctor about all other cancer medications you have received in the past, especially BiCNU, CeeNU, Cytoxan, DTIC-Dome, Gliadel, Leukeran, Myeleran, Neosar, Temodar, or Zanosar.
Do not use fluorouracil if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.
It is not known whether fluorouracil passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How is Adrucil (fluorouracil injection) given?
Fluorouracil is injected into a vein through an IV. A healthcare provider will give you this injection.
Your first dose of fluorouracil will be given in a hospital setting where you can be closely watched in case the medication causes serious side effects.
Fluorouracil injections are usually given daily for 3 or 4 days in a row, and then every other day for another 3 or 4 days. This treatment cycle may be repeated once a month. You may also receive a weekly dose. Follow your doctor's instructions.
How often you need fluorouracil injections will depend on many factors, including side effects and how your body responds to the medication. Try not to miss any appointments for your fluorouracil injections.
Fluorouracil can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the medicine is injected.
What happens if I miss a dose?
Contact your doctor if you miss an appointment for your fluorouracil injection.
Fluorouracil Pregnancy Warnings
Animal studies revealed evidence of embryolethality and teratogenicity (i.e., abortion, resorptions, delays in growth, cleft palate, skeletal defects, deformed appendages [paws and tails], micro-anophthalmos) at doses lower than the human dose of 12 mg/kg. There are no controlled data in human pregnancy. AU TGA pregnancy category D: Drugs which have caused, are suspected to have caused or may be expected to cause, an increased incidence of human fetal malformations or irreversible damage. These drugs may also have adverse pharmacological effects. Accompanying texts should be consulted for further details. US FDA pregnancy category D: There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
AU, UK: Contraindicated US: This drug should be used during pregnancy only if the benefit outweighs the risk. AU TGA pregnancy category: D US FDA pregnancy category: D Comments: -Based on its mechanism of action, this drug can cause fetal harm when administered to a pregnant woman. -Women of childbearing potential should be advised to avoid becoming pregnant and to use an effective method of contraception during therapy with this drug and for up to 6 months after discontinuing therapy. -If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be advised of the potential hazard to the fetus and genetic counseling is recommended. -Men treated with this drug should be advised not to father a child during and for up to 6 months after discontinuing therapy. Advice men on conservation of sperm because of the possibility of irreversible infertility due to therapy.