Adapalene and Benzoyl Peroxide

Name: Adapalene and Benzoyl Peroxide

What are some other side effects of Adapalene and Benzoyl Peroxide?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at


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Pharmacologic Category

  • Acne Products
  • Topical Skin Product
  • Topical Skin Product, Acne


Benzoyl peroxide releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids.

Adapalene is a retinoid-like compound which is a modulator of cellular differentiation, keratinization, and inflammatory processes, all of which represent important features in the pathology of acne vulgaris.


Via the skin


Benzoyl peroxide: Converted to benzoic acid in skin


Adapalene: Primarily through bile; Benzoyl peroxide: Urine

Dosing Adult

Acne vulgaris: Adapalene 0.1%//benzoyl peroxide 2.5% or Adapalene 0.3%/benzoyl peroxide 2.5%: Topical: Apply to affected areas of skin once daily.

Dosing Geriatric

Refer to adult dosing.

Dosing Hepatic Impairment

There are no dosage adjustments provided in manufacturer’s labeling; however, systemic absorption is not extensive making the need for a dose adjustment unlikely.

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience burning, dryness, redness, scaling, or stinging. Have patient report immediately to prescriber severe skin irritation (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating, and advising patients.