Actidose

Name: Actidose

Usage during pregnancy or lactation

Safe use during pregnancy and lactation has not been established. Actidose® with Sorbitol and Actidose®-Aqua should be used during pregnancy or lactation only if the potential benefit justifies the potential risk. No teratogenic effects have been noted in rabbits or rats.

Actidose Dosage and Administration

Prior to administration of Actidose® with Sorbitol or Actidose®-Aqua, shake the container thoroughly for a minimum of 30 seconds. After administration of either Actidose® with Sorbitol or Actidose®-Aqua, the container should be thoroughly rinsed with water and any residue should be administered to the patient to ensure that the entire dose has been delivered.

Single Dose - Actidose®-Aqua

Under one year of age:

1 gm/kg (5 ml/kg)

1 – 12 years of age:

25-50 gm (120-240 ml)

Adults (over 12 yrs.):

50-100 gm (240-480- ml)

Single Dose - Actidose® with Sorbitol

Under one year of age:

DO NOT USE Actidose® WITH

SORBITOL IN CHILDREN LESS

THAN ONE YEAR OF AGE.

1 – 12 years of age:

DO NOT USE Actidose® WITH

SORBITOL 25 GM/120 ML IN

CHILDREN WEIGHING LESS

THAN 16 KG (35 LBS).

DO NOT USE Actidose® WITH

SORBITOL 50 GM/240 ML IN

CHILDREN WEIGHING LESS

THAN 32 KG (70 LBS).

Adults (over 12 yrs.):

50 gm [96 gm sorbitol]

(240 ml)

Multiple Dose - Actidose®-Aqua

Under one year of age:

1 gm/kg (5 ml/kg)

q 4-6H (every 4-6 hrs)

1 – 12 years of age:

25-50 gm (120-240 ml)

q 4-6H (every 4-6 hrs)

Adults (over 12 yrs.):

50-100 gm (240-480 ml)

q 4-6H (every 4-6 hrs)

Multiple Dose - Actidose® with Sorbitol

Actidose® WITH SORBITOL

IS NOT RECOMMENDED FOR

CHILDREN OR ADULTS IN

MULTIPLE DOSE ACTIVATED

CHARCOAL THERAPY DUE TO

EXCESSIVE CATHARTIC ACTION.

References

1. Activated Charcoal, Antidotal and Other Medicinal Uses, Marcel Dekker, New York, 1980. 2. Clinical Pharmacokinetics. 1982; 7: 465-489. 3. Handbook of Common Poisonings in Children, American Academy of Pediatrics, Evanston, 1983. 4. Am J Emerg Med. 1985; 3: 280-283. 5. Poisindex Information System, Micromedix, Denver, 1991. 6. J Pediatrics. 1981; 98: 157-158. 7. Diabetes Care. 1978; 1: 223-230. 8. Clinical Toxicology. 1985; 22: 529-536. 9. Ann. Emerg. Med. 1985; 14: 1152-1155. 10. Clinical Toxicology. 1985; 23: 579-587. 11. J. Pharmacol. Exp. Ther. 1982; 221: 656-663. 12. Am. J. Hosp. Pharm. 1978, 35: 1355-1359. 13. Lancet. 1981; 2: 1177-1178. 14. NEJM. 1982; 307: 676-678. 15. NEJM. 1982; 307: 642-644. 16. Clin. Pharmacol. Therap. 1983; 34: 663-666. 17. Medical Toxicology. New York, Elsevier, 1988. 18. Clinical Management of Poisoning and Drug Overdose. Philadelphia, W.B. Saunders Co., 1990. 19. Arch Intern Med. 1987; 147: 1390-1392. 20. ClinToxicol. 1989; 27: 91-99. 21. Ann Emerg Med. 1988; 17: 595-598. 22. Ann Emerg Med. 1990; 19: 453. 23. Ann Emerg Med. 1987; 16: 164-166. 24. Ann Emerg Med. 1991; 20: 529-531. 25. J. Pediatrics. 1986; 109: 719-722. 26. Ann Emerg Med. 1986; 15: 1214-1218. 27. J. Pediatrics. 1988; 112: 333. 28. Vet Hum Toxicol. 1989; 31: 335. 29. B Med J. 1988; 297: 459-460. 30. NCMJ. 1990; 51: 79-80. 31. Ann Emerg Med. 1981; 10: 528-529. 32. Chest. 1989; 96: 672-674. 33. J Emerg Med. 1986; 4: 401-407.

Manufactured By

Perrigo®

Minneapolis, MN 55427

2122016

(04-12)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Usual Adult Dose for Gastrointestinal Decontamination

Activated Charcoal:
Single-dose: 25 to 100 g orally or by nasogastric tube once, as a slurry in water. The routine use of single-dose activated charcoal is not recommended.

Multiple-dose:
Initial dose: 50 to 100 g orally or by nasogastric tube, as a slurry in water
Maintenance dose: 12.5 g every hour, 25 g every 2 hours, or 50 g every 4 hours until symptoms resolve.

Renal Dose Adjustments

No adjustment recommended

(web3)