Name: Acetic Acid
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Uses for Acetic Acid
Bacteriuria and Bacteremia Associated with Indwelling Catheters
Constant or intermittent irrigation of the urinary bladder to help prevent growth and proliferation of susceptible urinary pathogens (especially ammonia-forming bacteria) associated with prolonged use of an indwelling urethral catheter.1 2 3 4 5 6
Maintaining Patency of Indwelling Catheters
Periodic irrigation of an indwelling urethral catheter to help maintain patency.1 2 3 4
Acetic Acid Dosage and Administration
Acetic acid irrigating solution contains 0.25% acetic acid; this preparation should not be confused with Acetic Acid NF, which contains 36–37% of the acid, or with Diluted Acetic Acid NF, which contains 5.7–6.3% of the acid.1
Used for irrigation only; do not administer by IV injection or any other parenteral route.1 2 3 4
For constant or intermittent irrigation of the urinary bladder, administer by gravity drip via a disposable administration set connected to an indwelling urethral catheter designed for continuous or intermittent 2-way flow.1 2 4 For periodic irrigation of an indwelling urethral catheter, may use a bulb or piston syringe to administer and aspirate solution.1 4
Use aseptic technique to prepare and administer solution.2 Do not use unless solution is clear, seal is intact, and container is undamaged.2 3 4 Use contents promptly after opening container to minimize possibility of bacterial growth or pyrogen formation.2 3 4
Use new (unused) container for each initial or repeat procedure.2 Use separate containers for each patient.2
Discard unused portion since acetic acid irrigating solution contains no preservatives.2 3 4Rate of Administration
Continuous or intermittent irrigation: Rate will approximate urine flow rate and should be adjusted to maintain a urinary effluent pH of 4.5–5.1 2 4 Use nitrazine or other pH paper to monitor pH, preferably at least 4 times daily.1 2 4
AdultsBacteriuria and Bacteremia Associated with Indwelling Catheters Urologic Irrigation
Continuous or intermittent irrigation of urinary bladder: Approximately 500–1500 mL of 0.25% acetic acid irrigating solution every 24 hours.1 2 4Maintaining Patency of Indwelling Catheters Urologic Irrigation
Periodic irrigation of indwelling urethral catheter: Approximately 50 mL of 0.25% acetic acid solution per irrigation;1 4 may irrigate as often as desired.4
Cautions for Acetic Acid
Irrigation during transurethral surgical procedures.1 2 4
WarningsAppropriate Use of Acetic Acid 0.25% Irrigating Solution
For urologic irrigation only.2 4
Use in patients with urinary bladder mucosal lesions may cause lesion irritation.1 2 3 4 Systemic absorption of acetic acid via open lesions may result in systemic acidosis.1 2 3 4 (See Systemic Acidosis under Cautions.) If systemic absorption occurs, discontinue irrigation and evaluate patient for possible systemic acidosis, intravascular hemolysis, and circulatory overload; institute appropriate therapy as needed.2 4
Major ToxicitiesSystemic Acidosis
Systemic acidosis reported in patients receiving 0.25% acetic acid solution for irrigation of the urinary bladder; may occur following absorption of acetic acid via open lesions of the bladder mucosa.1 2 3 4 (See Appropriate Use of Acetic Acid 0.25% Irrigating Solution under Cautions.)
If systemic acidosis occurs, discontinue irrigation, reevaluate patient, and institute appropriate therapy.2 3Pain
Pain (i.e., urologic pain) reported in patients receiving 0.25% acetic acid solution for irrigation of the urinary bladder; if this occurs, discontinue irrigation, reevaluate patient, and institute appropriate therapy.1 2 3 4Hematuria
Hematuria reported in patients receiving 0.25% acetic acid solution for irrigation of the urinary bladder; if this occurs, discontinue irrigation, reevaluate patient, and institute appropriate therapy.1 2 3 4
Category C.2 3 4Lactation
Caution advised if acetic acid 0.25% irrigating solution is used in nursing women.2 4Pediatric Use
Safety and efficacy not established in pediatric patients.2 3 4Geriatric Use
Insufficient experience in patients >65 years of age to determine whether geriatric patients respond differently than younger adults.2 Systemic absorption unlikely (unless open lesions of the bladder mucosa are present); however, increased sensitivity cannot be ruled out.2
Common Adverse Effects
Systemic acidosis,2 3 4 pain/urologic pain,2 3 4 hematuria.2 3 4 5
Exerts antimicrobial action against a variety of microorganisms (especially ammonia-forming bacteria) that often gain access to the urinary bladder in patients requiring prolonged indwelling urethral catheterization.1 2 4 Antimicrobial activity depends on administration at sufficient rate (continuous or intermittent) to maintain effluent pH ≤5.1 2 (See Rate of Administration under Dosage and Administration.)
Reduces formation of calcium encrustations in indwelling catheter by maintaining low urine pH.1 2 4
Advice to Patients
Importance of reporting any adverse effects (e.g., pain, hematuria) to a clinician.2 3 4
Importance of understanding that acetic acid solution is intended for urologic irrigation only.1 2 3 4
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.
Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.2 3 4
Importance of informing patients of other important precautionary information.1 (See Cautions.)
Acetic Acid Description
Acetic Acid Otic Solution, USP is a nonaqueous solution of glacial Acetic Acid, USP (2%), in a propylene glycol vehicle containing benzethonium chloride, USP (0.02%); propylene glycol diacetate, NF (3%) and sodium acetate, USP (0.015%). It may also contain citric acid, USP.
The molecular formula for Acetic Acid is CH3COOH, with a molecular weight of 60.05. The structural formula is:
Acetic Acid Otic Solution is available as a nonaqueous otic solution buffered at pH 3 for use in the external ear canal.
For the treatment of superficial infections of the external auditory canal caused by organisms susceptible to the action of the antimicrobial.
Discontinue promptly if sensitization or irritation occurs.
What is acetic acid (acetasol)?
Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or fungus.
Acetic acid is used to treat infections in the ear canal. This medication will not treat an inner ear infection (also called otitis media).
Acetic acid may also be used for purposes other than those listed in this medication guide.