Acetaminophen, Caffeine, and Isometheptene Mucate

Name: Acetaminophen, Caffeine, and Isometheptene Mucate

How is this medicine (Acetaminophen, Caffeine, and Isometheptene Mucate) best taken?

Use acetaminophen, caffeine, and isometheptene mucate as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Take with or without food. Take with food if it causes an upset stomach.

What do I do if I miss a dose?

  • If you take this medicine on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times acetaminophen, caffeine, and isometheptene mucate is taken on an as needed basis. Do not take more often than told by the doctor.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take acetaminophen, caffeine, and isometheptene mucate or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to acetaminophen, caffeine, and isometheptene mucate. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017

Index Terms

  • Caffeine, Acetaminophen, and Isometheptene
  • Caffeine, Isometheptene Mucate, and Acetaminophen
  • Isomethepten/Caf/Acetaminophen
  • Isometheptene Mucate, Acetaminophen, and Caffeine
  • Isometheptene/Acetaminoph/Caff

Brand Names U.S.

  • Prodrin

Pharmacology

Acetaminophen: Nonopioid analgesic which reduces the perception of pain impulses originating from dilated cerebral vessels.

Caffeine: A cranial vasoconstrictor to enhance the vasoconstrictor effect. It is also used as a central stimulant for relief of headache.

Isometheptene mucate: Sympathomimetic amine which acts by constricting dilated cranial and cerebral arterioles, thus reducing the stimuli that lead to vascular headaches.

Dosing Geriatric

Refer to adult dosing.

ALERT U.S. Boxed Warning

Hepatotoxicity:

Acetaminophen has been associated with cases of acute liver failure at times resulting in liver transplant and death. Most of the cases of liver injury are associated with the use of acetaminophen at doses that exceed 4,000 mg/day, and often in combination with other acetaminophen-containing products.

Warnings/Precautions

Concerns related to adverse events:

• Hepatotoxicity: [U.S. Boxed Warning]: Acetaminophen may cause severe hepatic toxicity, potentially requiring liver transplant or resulting in death; hepatotoxicity is usually associated with excessive acetaminophen intake (≥4 g/day) and often in combination with other acetaminophen-containing products. Risk of acute liver failure is increased in patients with active liver disease or concomitant use of alcohol. Have patients avoid ethanol or limit to <3 drinks/day.

• Hypersensitivity/anaphylactic reactions: Hypersensitivity and anaphylactic reactions have been reported with acetaminophen use; discontinue immediately if symptoms of allergic or hypersensitivity reactions occur.

• Skin reactions: Rarely, acetaminophen may cause serious and potentially fatal skin reactions, such as acute generalized exanthematous pustulosis, Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN). Discontinue treatment if severe skin reactions develop.

Concurrent drug therapy issues:

• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.

Disease-related concerns:

• Cardiovascular disease: Use caution in patients with cardiovascular disease, including hypertension and peripheral vascular disease, or after recent cardiovascular attack. Use is contraindicated in organic heart disease.

Other warnings/precautions:

• Dosage limit: Limit acetaminophen dose from all sources (prescription and OTC) to ≤4 g/day.

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