Accuretic

Name: Accuretic

Uses

This medication is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.This product contains two medications, quinapril and hydrochlorothiazide. Quinapril belongs to a class of drugs known as ACE inhibitors. It works by relaxing blood vessels so blood can flow more easily. Hydrochlorothiazide (or "The thiazide diuretic") increases the amount of urine you make, removing extra water and salt from your body. These medications are used together when one drug is not controlling your blood pressure.OTHER This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.This medication may also be used to treat congestive heart failure.

Missed dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

What is Accuretic (hydrochlorothiazide and quinapril)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Quinapril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Quinapril lowers blood pressure and also relieves symptoms of fluid retention.

Hydrochlorothiazide and quinapril is a combination medicine used to treat hypertension (high blood pressure).

Hydrochlorothiazide and quinapril may also be used for purposes not listed in this medication guide.

Uses of Accuretic

Accuretic is a prescription medication used to treat high blood pressure.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

Manufacturer

  • Pfizer U.S. Pharmaceuticals Group

Side Effects of Accuretic

Serious side effects have been reported with Accuretic. See the "Accuretic Precautions" section. 

Common side effects of Accuretic include the following:

  • headache
  • dizziness
  • coughing
  • tiredness (fatigue)
  • muscle pain
  • viral infection
  • stuffy nose (rhinitis)
  • nausea and/or vomiting
  • stomach (abdominal) pain
  • back pain
  • diarrhea
  • infection that affects the nose, throat, and airways (upper respiratory infection)
  • difficulty sleeping (insomnia)
  • sleepiness (somnolence)
  • Inflammation of the airway which carries air to and from the lungs (bronchitis)
  • indigestion
  • abnormal physical weakness or lack of energy (asthenia)
  • widening of blood vessels (vasodilation)
  • feeling like your surroundings are spinning (vertigo)
  • chest pain

This is not a complete list of Accuretic side effects. Ask your doctor or pharmacist for more information. 

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 

Inform MD

Before taking Accuretic, tell your doctor about all of your medical conditions. Especially tell your doctor if:

  • are allergic to Accuretic or to any of its ingredients or to other sulfonamide-derived drugs
  • kidneys are unable to produce urine (anuric) or have kidney problems
  • history of a type of swelling that affects deeper layers in your skin, often around your eyes and lips (angioedema) with other ACE inhibitors
  • are diabetic, especially if you are taking aliskiren (Tekturna)
  • you are about to have major surgery
  • you are breastfeeding or plan to breastfeed
  • you are pregnant or planning to become pregnant

Tell you doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. 

Accuretic and Lactation

Tell your doctor is you are breastfeeding or plan to breastfeed. 

Accuretic's two ingredients, quinapril and hydrochlorothiazide, have been detected in human breast milk. Because of the possibility for adverse reactions in nursing infants from Accuretic, a choice should be made whether to stop nursing or to stop use of this medication. The importance of the drug to the mother should be considered. 

Accuretic Overdose

If you take too much Accuretic, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. 

Other Requirements

  • Store at room temperature, 68–77°F (20–25°C).
  • Dispense in a tight container.
  • Keep this and all medications out of the reach of children. 

Pharmacology

Mechanism of Action

Accuretic is a fixed-combination tablet that combines an angiotensin-converting enzyme (ACE) inhibitor, quinapril hydrochloride, and a thiazide diuretic, hydrochlorothiazide

Quinapril competitively inhibits angiotensin-converting enzymes resulting in decreased plasma angiotensin II concentrations and consequently, blood pressure may be reduced in part through decreased vasoconstriction, increase renin activity, and decrease aldosterone secretion

Hydrochlorothiazide is a thiazide diuretic that inhibits Na reabsorption in distal renal tubules resulting in increased excretion of Na+ and water, also K+ and H+ ions

Pharmacokinetics

Quinapril

  • Half-Life: 0.8 hr (quinapril); 3 hr (quinaprilat)
  • Onset: 1 hr
  • Duration: 24 hr
  • Peak Plasma Time: 1 hr (quinapril); 2 hr (quinaprilat)
  • Bioavailability: ≥60%
  • Protein Bound: 97%
  • Metabolite: Quinaprilat (active)
  • Metabolism: Liver
  • Excretion: Urine (50-60% primarily as quinaprilat)
  • Dialyzable: Minimally

Hydrochlorothiazide

  • Half-Life: 6-15 hr
  • Bioavailability: 70%
  • Onset: 2 hr (diuresis); 4-6 hr (peak effect)
  • Duration: 6-12 hr (diuresis); 1 wk (HTN)
  • Vd: 3.6-7.8 L/kg
  • Peak Plasma:1.5-2.5 hr
  • Protein Bound: 68%
  • Metabolism: Minimally metabolized
  • Clearance: 335 mL/min
  • Excretion: Urine 50-70%
  • Dialyzable: No
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